My favorite Hex editor is the excellent Hex Workshop. However, having just made the switch to Vista x64, I found that 32 bit shell extensions (which are COM dll’s) can not be loaded by 64 bit processes such as explorer.exe. So I hade a quick look around and came across this article by Michael Dunn and from this I have created an x64 shell extension for Hex Workshop. Feel free to download it here, just copy it to your Hex Workshop folder and register it. It was built using Visual Studio 2008, so you may need the latest MS runtime’s.
C:Program Files (x86)BreakPoint SoftwareHex Workshop v5>regsvr32 hwext64.dll